Detox Options

Detox Options

The Naltrexone Implant Center provides detox options, several of which are listed below. Please contact us to discuss which of our detox options, if any, would be appropriate for you before receiving the OLANI.

Benzodiazepines Detox

Benzodiazepines reduce anxiety. However, extended use can often lead to lowered tolerance, meaning that an individual needs to take more to achieve the same effect.

Increased dosage also increases withdrawal symptoms when an individual attempts to stop. For individuals who wish to stop taking benzodiazepines, we have found that it is possible to comfortably overcome those withdrawal symptoms with an infusion of flumazenil.

Flumazenil can be thought of as a benzodiazepine blocker. By using a low dose flumazenil protocol developed by Dr. O’Neil, the benzodiazepine receptors in the brain are thought to ‘reset’, reducing the individual’s urge to take benzodiazepines. Research has demonstrated that flumazenil also helps reduce anxiety and physical symptoms associated with withdrawal.

The dose of flumazenil is very low and is administered in a continuous flow through a very fine needle placed just under the skin in the abdominal area. The flumazenil is mixed with a small amount of saline and placed into a portable infusion device, an inhouse product, invented and developed by Dr. O’Neil. The device is monitored twice daily. The procedure typically takes 4 days, but can be extended in severe cases.

The dose of flumazenil is not high enough to prevent benzodiazepine overdose, either during or after treatment. This treatment is not protection from overdose. It is a method which eases or eliminates withdrawal symptoms for people stopping benzodiazepine use.

Short-Acting Opiate & Buprenorphine Detox

Individuals who detox with us can detox in four days.

Since the invention of the OLANI, implant naltrexone has become our preferred treatment for opiates.

If a patient has been using opiates in the days leading up to treatment, naltrexone can facilitate an accelerated detoxification. Withdrawal symptoms will be significantly shorter in duration, which means that our staff can monitor the process and medication can be administered to reduce the symptoms. Still, we strongly advise that patients reduce their opiate use leading up to treatment.

We do have gentler detox options available. Please contact us to discuss whether these options would be suitable for you.

Individuals who undergo detoxification of any type need to be very careful if they choose to start using opiates again.


Detox from methadone can be more difficult than from other opiates. We recommend that methadone users go through a two week process of changing to buprenorphine before receiving the OLANI.

Dr. O’Neil has used this method for about ten years, even for users who have found it too difficult to detox from high dose methadone (about 100 mg/day). Users are encouraged to skip their methadone dose the day before switching to buprenorphine, and again on the day they receive their OLANI. We prescribe a course of buprenorphine treatment that lasts up to 14 days with medications to control detox symptoms, if necessary. The OLANI can be implanted two weeks after the patient’s first day of detox.

Again, contact us to discuss our gentler detox options and whether they would be a good fit for you.

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